Mechanism Of Interaction Between Pioglitazone Hydrochloride And Bovine Transferrin By Spectroscopic And Molecular Docking Methods

Authors

  • C.D. Wang
  • B. Liu
  • G. Bian
  • L.H. Ma
  • C. Zhang
  • X. Cheng D

Keywords:

Spectrometry, Molecular Docking, Pioglitazone Hydrochloride, Bovine Transferrin, Interaction Mechanism

Abstract


The binding of pioglitazone hydrochloride with bovine transferrin was investigated by spectroscopic and molecular docking methods under different temperature conditions (298, 310 and 318 K). The results demonstrate that the interaction between pioglitazone hydrochloride and bovine transferrin is taking place via static quenching with 1:1 binding ratio. The fluorescence data were treated by using the double logarithmic equation, and the binding constants Ka of the interaction of pioglitazone hydrochloride-bovine transferrin systems and the number of binding sites n were obtained. The thermodynamic parameters of pioglitazone hydrochloride-bovine transferrin systems under different temperatures were obtained by the thermodynamic equation. The experimental data show that the interactions between them are mainly electrostatic force interaction, which is consistent with the molecular docking results.

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Published

2018-12-19

How to Cite

Wang, C., Liu, B., Bian, G., Ma, L., Zhang, C., & Cheng D, X. (2018). Mechanism Of Interaction Between Pioglitazone Hydrochloride And Bovine Transferrin By Spectroscopic And Molecular Docking Methods. Journal of Engineering and Technology (JET), 9(2), 61–76. Retrieved from https://jet.utem.edu.my/jet/article/view/3694

Issue

Vol. 9 No. 2 (2018): JOURNAL OF ENGINEERING AND TECHNOLOGY

Section

Articles

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